adipocyte enhancer-binding protein 1 (AE-binding protein 1, aortic carboxypeptidase-like protein, AEBP1, ACLP)

Function

• may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation & reduced adipocyte differentiation
• may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation & subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage
• inflammatory responsiveness (putative)
• can act as a transcriptional repressor (putative)
• interacts with GNG5, NFKBIA, MAPK1, MAPK3 & PTEN
• may interact with calmodulin (putative)
• binds to DNA in vitro (putative)
• phosphorylated by MAPK1 in vitro (putative)

Structure

• belongs to the peptidase M14 family
• protein has lost active site residues & Zn+2-binding sites & so is unlikely to be catalytically active
• contains 1 F5/8 type C domain

Compartment

• isoform 1: secreted (putative)
• isoform 2: cytoplasm (probable), nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in osteoblast & visceral fat

More general terms

• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:165
• OMIM: https://mirror.omim.org/entry/602981
• UniProt: http://www.uniprot.org/uniprot/Q8IUX7.html