testis anion transporter 1; anion exchange transporter; solute carrier family 26 member 8 (SLC26A8, TAT1)
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Function
- acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate & oxalate transport.
- may fulfill critical anion exchange functions in male germ line during meiosis & hence may play a role in spermatogenesis
- may be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells
- critical component of the sperm annulus that is essential for correct sperm tail differentiation & motility & hence male fertility
- interacts with RACGAP1
Inhibition:
- repressed by tunicamycin, an inhibitor of N-glycosylation
- activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS) - an inhibitor of several anionic channels & transporters, gluconate, & by thiosulfate
Structure
- N-glycosylated
- belongs to the SLC26A/sulP transporter (TC 2.A.53) family
- contains 1 STAS domain
Compartment
- membrane
- located at the annulus ring structure within the sperm cell
Alternative splicing
named isoforms=4
Expression
- expression observed exclusively in testis
- restricted to the meiotic phase of the germ cell
- abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes & spermatids
- expressed in spermatozoa
More general terms
- glycoprotein
- solute carrier family 26 (SLC26, SLC26A)
- transmembrane 12 protein
- testis-specific protein