anion exchange transporter; solute carrier family 26 member 7 (SLC26A7, SUT2)

Function

• acts as a Na+-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate & oxalate transport
• may play a role in the maintenance of the electrolyte & acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger
• plays a major role in gastric acid secretion
• active at both alkaline & acidic pH

Inhibition:

• activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS) - an inhibitor of several anionic channels & transporters

Structure

• belongs to the SLC26A/sulP transporter (TC 2.A.53) family
• contains 1 STAS domain

Compartment

• endosome, membrane
• expressed in cytoplasm in recycling endosomes of medullary collecting duct cells & in acid-secreting gastric parietal cells
• targeted to the basolateral membrane in hypertonicity & K+ depletion

Alternative splicing

named isoforms=2

Expression

• expressed in tonsilar high endothelial venule enothelial cells (HEVEC), placenta
• in testis, expressed in a subgroup of basal cells in the epididymal ducts

More general terms

• transmembrane 10 protein
• solute carrier family 26 (SLC26, SLC26A)

Additional terms

• testis anion transporter 1; anion exchange transporter; solute carrier family 26 member 8 (SLC26A8, TAT1)

Database

• OMIM: https://mirror.omim.org/entry/608479
• UniProt: http://www.uniprot.org/uniprot/Q8TE54.html