polycystic kidney disease protein 1-like 2 (polycystin-1L2, PC1-like 2 protein, PKD1L2, KIAA1879, PC1L2)

Function

• may function as an ion-channel regulator
• may function as a G-protein-coupled receptor
• may interact via its C-terminus with GNAS & GNAI1

Structure

• belongs to the polycystin family
• contains 1 C-type lectin domain
• contains 1 GPS domain
• contains 1 PLAT domain contains 1 REJ domain contains 1 SUEL-type lectin domain

Compartment

membrane (putative)

Alternative splicing

named isoforms=7

Expression

• expressed in all tissues tested including brain, placenta, mammary gland, testis, lung & liver.
• highest expression in skeletal muscle
• isoform 2 is expressed in heart & kidney
• expressed in fetal heart

More general terms

• glycoprotein
• transmembrane 12e protein

Database

• OMIM: https://mirror.omim.org/entry/607894
• UniProt: http://www.uniprot.org/uniprot/Q7Z442.html