DAN domain family member 5 (cerberus-like protein 2, cerl- 2, Gremlin-3, cysteine knot superfamily 1, BMP antagonist 3) (DAND5 CER2 CKTSF1B3 GREM3 SP1)

Function

• seems to play a role in the correct specification of the left-right axis
• may antagonize NODAL & BMP4 signaling
• cystine knot-containing proteins play important roles during development, organogenesis, tissue growth & differentiation (putative)

Structure

• belongs to the DAN family
• contains 1 CTCK (C-terminal cystine knot-like) domain

Compartment

secreted (probable)

More general terms

• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N907.html