hyaluronan-binding protein 2; plasma hyaluronan-binding protein; hepatocyte growth factor activator-like protein; factor VII-activating protease; factor seven-activating protease; FSAP [Contains: hyaluronan-binding protein 2 50 kD heavy chain; hyaluronan-binding protein 2 50 kD heavy chain alternate form; hyaluronan-binding protein 2 27 kD light chain; hyaluronan-binding protein 2 27 kDa light chain alternate form] (HABP2, HGFAL, PHBP)

Function

• cleaves fibrinogen alpha-chain at multiple sites & fibrinogen beta-chain between Lys-53 & Lys-54
• does NOT cleave fibrinogen gamma-chain, thus does NOT initiate formation of fibrin clot & does NOT cause fibrinolysis directly
• does NOT cleave prothrombin & plasminogen but converts pro-urokinase) to active urokinase
• activates coagulation factor VII
• proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kD heavy chain & cleavage at Arg-313 or Lys-319 can give rise to the 27 kD light chain
• heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kD fragments
• light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kD & 8 kD fragments

Structure

• heterodimer; disulfide-linked
  • heterodimer of a 50 kD heavy chain & a 27 kD light chain linked by a disulfide bond
• belongs to the peptidase S1 family
• contains 3 EGF-like domains
  • contains 1 kringle domain
  • contains 1 peptidase S1 domain

Compartment

• secreted as an inactive single-chain precursor, activated to a heterodimeric form

More general terms

• protease; proteinase; endopeptidase
• glycoprotein
• secreted protein
• hyaluronan-binding protein

Database

• OMIM: https://mirror.omim.org/entry/603924
• UniProt: http://www.uniprot.org/uniprot/Q14520.html