tubulointerstitial nephritis antigen-like (tubulointerstitial nephritis antigen-related protein, TIN Ag-related protein, TIN-Ag-RP, glucocorticoid-inducible protein 5, oxidized LDL-responsive gene 2 protein, OLRG-2, TINAGL1, GIS5, LCN7, OLRG2, TINAGL, PP6614, PSEC0088, UNQ204/PRO230)

Function

• role in adrenocortical zonation & in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells

Structure

• glycosylated
• belongs to the peptidase C1 family
• contains 1 SMB domain (somatomedin B domain)

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in aorta, heart, placenta, kidney > skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow, thyroid > colon, small intestine, ovary, spleen, testis, prostate
• predominantly found in vascular smooth muscle cells, but also in cardiac & skeletal muscle cells & kidney

Pathology

• highly expressed in a colorectal adenocarcinoma cell line

More general terms

• glycoprotein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9GZM7.html