cytochrome P450 11B1 (CYP11B1, steroid-11-hydroxylase B1, steroid 11 beta-monooxygenase)

Function

• steroid 11-beta-hydroxylase activity
• 18 or 19-hydroxylation of steroids
• aromatization of androstendione to estrone

Compartment

mitochondrial membrane

Pathology

• defects in CYP11B1 are the cause of congenital adrenal hyperplasia type 4

Laboratory

• CYP11B1 gene mutation

More general terms

• cytochrome P450 11B (steroid-11-beta hydroxylase)

Database

• UniProt: http://www.uniprot.org/uniprot/P15538.html
• OMIM: https://mirror.omim.org/entry/103900
• OMIM: https://mirror.omim.org/entry/202010
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1584