testican-3 (SPARC/osteonectin, CWCV, & Kazal-like domains proteoglycan 3, SPOCK3, TICN3, UNQ409/PRO771)

Function

• role in neurogenesis (putative)
• inhibits processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP & MT3-MMP
• may interfere with tumor invasion

Structure

• contains chondroitin sulfate & heparan sulfate O-linked oligosaccharides
• contains 1 Kazal-like domain
• contains 1 thyroglobulin type-1 domain

Compartment

extracellular matrix

Alternative splicing

named isoforms=3

Expression

expressed in brain

More general terms

• matrix protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607989
• UniProt: http://www.uniprot.org/uniprot/Q9BQ16.html