neuronal cell adhesion molecule NRCAM (Nr-CAM, NgCAM-related cell adhesion molecule, Ng-CAM-related, hBravo, NRCAM, KIAA0343)

Function

• cell adhesion
• ankyrin-binding protein involved in neuron-neuron adhesion
• role in molecular assembly of nodes of Ranvier
• component of a neurofascin/NRCAM/ankyrin-G complex
• interacts with GLDN/gliomedin

Structure

• belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family
• contains 5 fibronectin F3 modules
• contains 6 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=5

Expression

• detected in all the examined tissues
• in brain, detected in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus & thalamus

More general terms

• neural cell adhesion molecule
• glycoprotein
• immunoglobulin superfamily protein

Database

• OMIM: https://mirror.omim.org/entry/601581
• UniProt: http://www.uniprot.org/uniprot/Q92823.html