gliomedin (cancer-related gene liver-2 protein, GLDN, COLM, UNQ9339/PRO34011)

Function

• role in formation of nodes of Ranvier along myelinated axons
• NRCAM & NFASC (neurofascin) ligand (probable)
  • binding via olfactomedin-like domain
• glial positional clue required for molecular assembly of nodes of Ranvier (putative)

Structure

• contains 2 collagen-like domains
• contains 1 olfactomedin-like domain

Compartment

cell membrane, localizes to the nodes of Ranvier

Alternative splicing

named isoforms=2

Expression

• expressed in spinal cord, brain, placenta, sciatic nerve
• more abundant in peripheral than central nervous system

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/608603
• UniProt: http://www.uniprot.org/uniprot/Q6ZMI3.html