ankyrin-3; ANK-3; ankyrin-G (ANK3)

Function

• membrane-cytoskeleton linker
• the neural-specific isoforms may participate in maintenance &/or targeting of ion channels & cell adhesion molecules at the nodes of Ranvier & axonal initial segments
• neural-specific isoforms may be a constituent of a neurofascin/NRCAM/ankyrin G complex
• interacts with RHBG

Structure

• contains 23 ANK repeats
• contains 1 death domain
• contains 1 ZU5 domain

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

Expression

• expressed in brain & other tissues
• isoform1 is neural-specific

More general terms

• ankyrin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=288
• OMIM: https://mirror.omim.org/entry/600465
• UniProt: http://www.uniprot.org/uniprot/Q12955.html