tumor necrosis factor-inducible protein TSG-6 (TNF-stimulated gene 6 protein, hyaluronate-binding protein, TNFAIP6, TSG6)

Function

• role in cell-cell & cell-matrix interactions during inflammation & tumorigenesis
• interacts with inter-alpha-inhibitor (I-alpha-I)
  • chondroitin sulfate may be required for the stability of the complex
• induced by TNF

Structure

• contains 1 CUB domain.
• contains 1 Link domain

Pathology

• found in synovial fluid of patients with rheumatoid arthritis

More general terms

• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600410
• UniProt: http://www.uniprot.org/uniprot/P98066.html