synaptic vesicle glycoprotein 2C (SV2C, KIAA1054)

Function

• control of regulated secretion in neural & endocrine cells
• selectively lenhances low-frequency neurotransmission
• positively regulates vesicle fusion by maintaining readily releasable pool of secretory vesicles (putative)
• interacts with SYT1 (Ca+-dependent)
• N-glycosylated

Compartment

• cytoplasmic vesicle, secretory vesicle, synaptic vesicle,
• synaptic vesicle membrane
• enriched in small <A19139>synaptic vesicles</A19139> & adrenal microsomes
• not present in chromaffin granules
• associated with both insulin granules & synaptic-like microvesicles in insulin-secreting cells of the pancreas

More general terms

• transmembrane 12 protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q496J9.html