myelin protein zero-like protein 1 (protein zero-related, MPZL1, PZR, UNQ849/PRO1787)

Function

• cell surface receptor
• signal transduction processes
• recruits PTPN11/SHP-2 to the cell membrane
• putative substrate of PTPN11/SHP-2
• receptor for concanavalin A (ConA)
  • cellular signaling induced by ConA
  • induces Src family tyrosine- protein kinases
  • isoform 3 with dominant negative role
    • blocks tyrosine phosphorylation of MPZL1 induced by ConA
• integrin-mediated cell motility (isoform 1 only)
• interacts with phosphorylated PTPN11/SHP-2
• contains ITIM motifs
• phosphorylated on TYR upon stimulation with pervanadate & concanavalin A (ConA)
• phosphorylation at Tyr-241 & Tyr-263 is required for interaction with PTPN11/SHP-2.
• dephosphorylated by PTPN11/SHP-2 (in vitro)

Alternative splicing

named isoforms=4

Expression

• widely expressed
• highest levels in heart, placenta, kidney, pancreas

More general terms

• cell surface receptor
• glycoprotein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604376
• UniProt: http://www.uniprot.org/uniprot/O95297.html