tolloid-like protein 1 (TLL1, TLL)

Function

• protease, processes procollagen C-propeptides
  • chordin, pro-biglycan and pro-lysyl oxidase
• embryonic development
• predominant protease influencing dorsal-ventral patterning & skeletogenesis in development

Cofactor: binds 1 Zn+2 per subunit

Structure

• belongs to the peptidase M12A family
• contains 5 CUB domains
• contains 2 EGF-like domains

Compartment

secreted (probable)

Alternative splicing

named isoforms=2

Pathology

• defects in TLL1 are the cause of atrial septal defect type 6

More general terms

• metalloprotease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7092
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7092
• OMIM: https://mirror.omim.org/entry/606742
• OMIM: https://mirror.omim.org/entry/613087
• UniProt: http://www.uniprot.org/uniprot/O43897.html