lysyl oxidase or protein lysine-6-oxidase

Function

• cross-linking of extracellular matrix proteins
• responsible for the post-translational oxidative deamination of Lys in precursors to fibrous collagen & elastin
• direct role in tumor suppression
• the Lys-Tyr quinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a Lys with a topaquinone produced by oxidation of Tyr
• propeptide plays a role in directing the deposition of enzyme to elastic fibers, via interaction with tropoelastin (putative)

peptidyl-L-lysyl-peptide + O2 + H2O
            <-->
peptidyl-allysyl-peptide + NH3 + H2O2

Cofactor: Copper

Structure

• belongs to the lysyl oxidase family
• contains 1 lysine tyrosylquinone (putative)

Compartment

secreted, extracellular space

Expression

• heart, placenta, skeletal muscle, kidney, lung & pancreas

Pathology

• defects in LOX may be a cause of autosomal recessive cutis laxa type 1

More general terms

• amino-acid oxidoreductase
• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P28300.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4015
• OMIM: https://mirror.omim.org/entry/153455
• OMIM: https://mirror.omim.org/entry/219100