K+ voltage-gated channel subfamily H member 5; ether-a-go-go K+ channel 2; hEAG2; voltage-gated K+ channel subunit Kv10.2 (KCNH5 EAG2)

Function

• pore-forming (alpha) subunit of voltage-gated K+ channel
• elicits a non-inactivating outward rectifying current
• channel properties may be modulated by cAMP & subunit assembly
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
• heteromultimer with KCNH1/EAG (probable)

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.2/KCNH5 sub-subfamily
• contains 1 cyclic nucleotide-binding domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 1 PAS (PER-ARNT-SIM) domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in brain, skeletal muscle, heart, placenta, lung & liver
• expressed at low levels in kidney

More general terms

• K+ channel subfamily H
• transmembrane 6 protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27133
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27133
• OMIM: https://mirror.omim.org/entry/605716
• UniProt: http://www.uniprot.org/uniprot/Q8NCM2.html