K+ voltage-gated channel subfamily H member 1; ether-a-go-go K+ channel 1; EAG channel 1; h-eag; hEAG1; voltage-gated K+ channel subunit Kv10.1 (KCNH1, EAG, EAG1)

Function

• pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier K+ channel
• channel properties may be modulated by cAMP & subunit assembly
• mediates IK(NI) current in myoblasts
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
• heteromultimer with KCNH5/EAG2
• interacts with ALG10B (putative)

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.1/KCNH1 sub-subfamily
• contains 1 cyclic nucleotide-binding domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 1 PAS (PER-ARNT-SIM) domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in brain & in myoblasts at the onset of fusion
• not expressed in other tissues
• detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) & MCF-7 (epithelial tumor) cells, but not in normal epithelial cells

More general terms

• K+ channel subfamily H
• transmembrane 6 protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3756
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3756
• OMIM: https://mirror.omim.org/entry/603305
• UniProt: http://www.uniprot.org/uniprot/O95259.html