K+ voltage-gated channel subfamily G member 3; voltage-gated K+ channel subunit Kv10.1; voltage-gated K+ channel subunit Kv6.3 (KCNG3)

Function

• K+ channel subunit
• modulates channel activity
• heteromultimer with KCNB1, KCNC1 & KCNF1
• does not form homomultimers

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, G (TC 1.A.1.2) subfamily, Kv6.3/KCNG3 sub-subfamily

Compartment

• cell membrane; multi-pass membrane protein
• has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane
• remains intracellular in the absence of KCNB1

Alternative splicing

named isoforms=2

Expression

• expressed in many parts of the brain
  • not expressed in cerebellum
• expressed in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland & spinal cord

More general terms

• K+ channel subfamily G
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=170850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:170850
• OMIM: https://mirror.omim.org/entry/606767
• UniProt: http://www.uniprot.org/uniprot/Q8TAE7.html