K+ voltage-gated channel subfamily H member 4; brain-specific eag-like channel 2; BEC2; ether-a-go-go-like K+ channel 1; ELK channel 1; ELK1; voltage-gated K+ channel subunit Kv12.3 (KCNH4)

Function

• pore-forming (alpha) subunit of voltage-gated K+ channel
• elicits an outward current, but shows no inactivation
• channel properties may be modulated by cAMP & subunit assembly
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv12.3/KCNH4 sub-subfamily
• contains 1 cyclic nucleotide-binding domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 1 PAS (PER-ARNT-SIM) domain

Compartment

membrane

Expression

• expressed only in brain, in particular in the telencephalon
• expressed in putamen & caudate nucleus
• expressed at lower levels in cerebral cortex, occipital & hippocampus

More general terms

• K+ channel subfamily H
• transmembrane 6 protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23415
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23415
• OMIM: https://mirror.omim.org/entry/604528
• UniProt: http://www.uniprot.org/uniprot/Q9UQ05.html