chondroadherin; cartilage leucine-rich protein (CHAD, SLRR4A)

Function

• promotes attachment of chondrocytes, fibroblasts, & osteoblasts; binding is mediated (at least for chondrocytes & fibroblasts) by the integrin alpha(2)beta(1)
• may play role in the regulation of chondrocyte growth & proliferation (putative)
• mostly monomeric (putative)
• interacts with collagen type 2

Structure

• belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily
• contains 11 LRR repeats (leucine-rich repeats)

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• present in chondrocytes at all ages

More general terms

• glycoprotein
• secreted protein
• leucine-rich repeat-containing protein (LRRC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1101
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1101
• OMIM: https://mirror.omim.org/entry/602178
• UniProt: http://www.uniprot.org/uniprot/O15335.html