UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kD subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kD subunit (OGT)

Function

• addition of nucleotide-activated sugars directly onto polypeptide through O-glycosidic linkage with the hydroxyl of Ser or Thr
• mediates O-glycosylation of MLL5
• protein modification; protein glycosylation
• heterotrimer of two 110 kD & one 70 kD subunits
• unknown if the 70 kD subunit is encoded by a separate gene or is the product of either of a proteolytic degradation or an alternative initiation of the 110 kD subunit (putative)
• interacts with ATXN10 (putative)
• component of the MLL5-L complex
• interacts with HCFC1

Structure

• belongs to the O-GlcNAc transferase family
• contains 13 TPR repeats

Compartment

cytoplasm (putative), nucleus

Alternative splicing

named isoforms=3

Expression

• highly expressed in pancreas
• lower expression in skeletal muscle, heart, brain & placenta
• present in trace amounts in lung & liver

More general terms

• protein subunit
• glycoprotein
• phosphoprotein

Component of

• O-GlcNAc transferase P100 subunit (OGT p100, UDP-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, O-GlcNAc transferase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8473
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8473
• OMIM: https://mirror.omim.org/entry/300255
• UniProt: http://www.uniprot.org/uniprot/O15294.html