ataxin-10; spinocerebellar ataxia type 10 protein; brain protein E46 homolog (ATXN10 SCA10)

Function

• necessary for the survival of cerebellar neurons
• induces neuritogenesis by activating the Ras - MAP kinase pathway (putative)
• may play a role in the maintenance of a critical intracellular glycosylation level & homeostasis
• interacts with OGT
• interacts with GNB2

Structure

• homooligomer (putative)
• belongs to the ataxin-10 family

Compartment

• cytoplasm, perinuclear region

Expression

• expressed in the central nervous system

Pathology

• ATTCT repeat expansion in intron 9 of SCA10 gene encoding ataxin-10 seen in spinocerebellar ataxia type 10

More general terms

• ataxin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25814
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25814
• OMIM: https://mirror.omim.org/entry/603516
• OMIM: https://mirror.omim.org/entry/611150
• UniProt: http://www.uniprot.org/uniprot/Q9UBB4.html