G-protein coupled receptor family C group 5 member B; A-69G12.1; retinoic acid-induced gene 2 protein; RAIG-2 (GPRC5B, RAIG2)

Function

• unknown
• retinoic acid-inducible G-protein coupled receptor

Structure

• belongs to the G-protein coupled receptor 3 family

Compartment

• cell membrane
• cytoplasmic vesicle membrane
• localized in the plasma membrane & perinuclear vesicles
• multi-pass membrane protein

Expression

• expression in kidney, pancreas, testis > brain, heart, prostate, small intestine, & spleen > liver, placenta, skeletal muscle, colon, ovary, & thymus
• not detectable in lung & peripheral leukocytes
• highly expressed in most brain areas
  • highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus
• expressed in spinal cord & in dorsal root ganglia
• in the periphery, expression levels are relatively low, compared to the CNS (this contrasts with statement above)
  • strongest expression detected in pancreas, testis, uterus, & stomach
• induced by all-trans retinoic acid (ATRA)

Notes

• uncertain whether Met-1 or Met-9 is the initiator
• GPRC5B may provide evidence for interaction(s) between retinoid(s) & G-protein signaling pathway(s)

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51704
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51704
• OMIM: https://mirror.omim.org/entry/605948
• UniProt: http://www.uniprot.org/uniprot/Q9NZH0.html