G-protein coupled receptor 87; G-protein coupled receptor 95 (GPR87, GPR95, FKSG78)

Function

• receptor for lysophosphatidic acid (LPA)
• necessary for TP53/p53-dependent survival in response to DNA damage

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• expressed in placenta & prostate
• weaker expression in thymus
• not expressed in thalamus, hippocampus, pons or cerebellum
• overexpressed in squamous cell carcinoma of the lung
• induced by expression of TP53 & by DNA damage (TP53-dependent)

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53836
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53836
• OMIM: https://mirror.omim.org/entry/606379
• UniProt: http://www.uniprot.org/uniprot/Q9BY21.html