G-protein coupled receptor 56; protein TM7XN1 (GPR56, TM7LN4, TM7XN1, UNQ540/PRO1083)

Function

• could be involved in cell-cell interactions

Structure

• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 1 GPS domain

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• widely distributed
• highest levels found in thyroid gland, brain & heart
• expressed in MANY tumor cells

Pathology

• defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9289
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9289
• OMIM: https://mirror.omim.org/entry/604110
• OMIM: https://mirror.omim.org/entry/606854
• UniProt: http://www.uniprot.org/uniprot/Q9Y653.html