uroplakin-1b; UP1b; uroplakin Ib; UPIb; tetraspanin-20; Tspan-20 (UPK1B TSPAN20)

Function

• component of the asymmetric unit membrane (AUM)
• role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (putative)
• heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) (putative)

Structure

• N-glycosylated with high-mannose oligosaccharides
• belongs to the tetraspanin (TM4SF) family

Compartment

membrane

Expression

bladder epithelium

More general terms

• transmembrane 4 protein
• uroplakin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7348
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7348
• OMIM: https://mirror.omim.org/entry/602380
• UniProt: http://www.uniprot.org/uniprot/O75841.html