uroplakin-3a; UP3a; uroplakin 3; UP3 (UPK3A UPK3)

Function

• component of the asymmetric unit membrane (AUM)
• role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells
• contributes to formation of urothelial glycocalyx which may function in preventing bacterial adherence
• heterodimer with uroplakin-1B (UPK1B) (putative)

Structure

• belongs to the uroplakin-3 family

Compartment

• endoplasmic reticulum membrane
• single-pass type 1 membrane protein (putative)
• heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER) (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in ureter

Pathology

• defects in UPK3A are a cause of renal agenesis

More general terms

• uroplakin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7380
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7380
• OMIM: https://mirror.omim.org/entry/191830
• OMIM: https://mirror.omim.org/entry/611559
• UniProt: http://www.uniprot.org/uniprot/O75631.html