G-protein coupled bile acid receptor 1 (membrane-type receptor for bile acids, M-BAR, hGPCR19, BG37, hBG37, GPBAR1, TGR5)

Function

• receptor for bile acids
• bile acid-binding induces internalization, activation of extracellular signal-regulated kinase & intracellular cAMP production
• suppression of macrophage functions by bile acids

Compartment

cell membrane

Expression

• ubiquitously expressed
• expressed in spleen, placenta > other tissues
• in digestive tissues, wxpressed in stomach, duodenum, jejunum, ileum, cecum, ascending colon, transverse colon, descending colon, liver
• NOT expressed in esophagus or rectum

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TDU6.html