cysteinyl leukotriene receptor 1 (CysLTR1, cysteinyl leukotriene D4 receptor, LTD4 receptor, HG55, HMTMF81)

Function

• receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with & without asthma
• stimulation by LTD4 results in contraction & proliferation of smooth muscle, edema, eosinophil migration & damage to the mucus layer in the lung
• this response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
• the rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• widely expressed, with highest levels in spleen & peripheral blood leukocytes
• lower expression in several tissues, such as lung (mostly in smooth muscle bundles & alveolar macrophages), placenta, small intestine, pancreas, colon & heart

Pharmacology

• selective antagonists, such as montelukast (singulair), zafirlukast (accolate) & pranlukast (Onon), are used in the treatment of the asthma

More general terms

• G-protein coupled receptor; serpentine receptor
• leukotriene receptor
• glycoprotein

Additional terms

• leukotriene C

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1080
• OMIM: https://mirror.omim.org/entry/300201
• UniProt: http://www.uniprot.org/uniprot/Q9Y271.html