CD314; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NK cell receptor D; killer cell lectin-like receptor subfamily K member 1 (KLRK1, D12S2489E, NKG2D)
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Function
- receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) & ULBP4
- plays a role as a receptor forrecognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- involved in the immune surveillance exerted by T-cells & B-cells
- interacts with DAP10
- interaction with DAP10 is required for NKG2D cell surface expression
Structure
- homodimer
- contains 1 C-type lectin domain
Compartment
membrane
Alternative splicing
named isoforms=1
A number of isoforms are produced
Expression
- natural killer cells
- expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC
- also detected in gamma-delta cells & CD8+ alpha-beta T-cells
- expressed in interferon-producing killer dendritic cells
Notes
- structurally distinct families of ligands for mouse & human NKG2D receptors have been characterized; they might be orthologs
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P26718.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/KLRK1ID41094ch12p13.html
- ↑ Functional Glycomics gateway - Glycan binding; Note: NKG-2D http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_246