interferon (IFN)-gamma receptor beta chain; interferon-gamma receptor accessory factor 1; AF-1; interferon-gamma transducer 1 (IFNGR2, IFNGT1)

Function

• accessory factor of interferon gamma receptor
• required for signal transduction
• integral part of IFN-gamma signal transduction
• likely to interact with GAF, JAK1, &/or JAK2

Structure

• belongs to the type 2 cytokine receptor family
• contains 2 fibronectin F3 modules

Compartment

membrane

Pathology

• defects in IFNGR2 are a cause of Mendelian susceptibility to mycobacterial disease

More general terms

• protein subunit
• plasma membrane protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3460
• OMIM: https://mirror.omim.org/entry/147569
• OMIM: https://mirror.omim.org/entry/209950
• UniProt: http://www.uniprot.org/uniprot/P38484.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3460