parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor (PTHR1, PTHR, PTH1R)
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Function
- receptor for parathyroid hormone (PTH) & for PTH-related peptide
- activity is mediated by G proteins which activate adenylyl cyclase & also a phosphatidylinositol-Ca+2- phospholipase C second messenger system
Structure
- belongs to the G-protein coupled receptor 2 family
Compartment
Expression
- expressed in most tissues
- most abundant in kidney, bone & liver
Pathology
- defects in PTHR1 are the cause of
More general terms
More specific terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q03431.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PTHR1
- ↑ Dunlay R, Hruska K. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney. Am J Physiol. 1990 Feb;258(2 Pt 2):F223-31. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2155534
- ↑ Schipani E et al A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 1995 Apr 7;268(5207):98-100. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7701349
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5745
- OMIM: https://mirror.omim.org/entry/156400
- OMIM: https://mirror.omim.org/entry/166000
- OMIM: https://mirror.omim.org/entry/168468
- OMIM: https://mirror.omim.org/entry/215045
- OMIM: https://mirror.omim.org/entry/600002
- UniProt: http://www.uniprot.org/uniprot/Q03431.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5745