glycodelin; GD; placental protein 14; PP14; pregnancy-associated endometrial alpha-2 globulin; PAEG; PEG; progestagen-associated endometrial protein; progesterone-associated endometrial protein (PAEP)

Function

• quantitatively, the main protein synthesized & secreted in the endometrium from mid-luteal phase of the menstrual cycle & during the first semester of pregnancy
• at least two differentially glycosylated forms are found
  • glycodelin-A (GdA) (amniotic fluid) with contraceptive & immunosuppressive activities
  • glycodelin-S (Gds) (seminal plasma) whose role is not yet known
• gender-specific glycosylation may serve to regulate a key process involved in human reproduction

Structure

• homodimer
• belongs to the calycin superfamily, lipocalin family

Compartment

secreted

Alternative splicing

named isoforms=3

More general terms

• alpha 2 globulin
• protein subunit
• glycoprotein
• lipocalin
• placental protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5047
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5047
• OMIM: https://mirror.omim.org/entry/173310
• UniProt: http://www.uniprot.org/uniprot/P09466.html