guanine deaminase (guanase, guanine aminase, guanine aminohydrolase, GAH, p51-nedasin, GDA)

Function

• catalyzes deamination of guanine producing xanthine & NH3

                GDA
Guanine + H2O    <-->    xanthine + NH3

Cofactor: binds 1 Zn+2 per subunit

Structure

• homodimer
• belongs to the ATZ/TRZ family

More general terms

• aminohydrolase (deaminase)
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9615
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9615
• OMIM: https://mirror.omim.org/entry/139260
• UniProt: http://www.uniprot.org/uniprot/Q9Y2T3.html