ERO1-like protein beta; ERO1-L-beta; endoplasmic oxidoreductin-1-like protein B; oxidoreductin-1-L-beta (ERO1LB)
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Function
- oxidoreductase
- provides oxidizing equivalents in the endoplasmic reticulum (ER) for the formation of disulfide bonds
- directly oxidizes P4HB/PDI isomerase via direct disulfide exchange
- does NOT act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent
- does not oxidize all PDI related proteins
- reoxidation involves electron transfer to O2 via FAD
- association with TXNDC4 retains ERO1LB in the ER
Structure
- monomer & homodimer
- belongs to the EROs family
Compartment
endoplasmic reticulum, lumenal side
Expression
- widely expressed at low level
- expressed at high level in lower digestive tract
- expressed in stomach & duodenum > esophagus
Pathology
- source of oxidative stress
- produces reactive oxygen species (ROS) {H2O2}
- induced by unfolded protein response