deoxyribonuclease-2-beta; Dnase II-like acid Dnase; Dnase2-like acid Dnase; deoxyribonuclease II beta; Dnase II beta; endonuclease DLAD (DNASE2B, DLAD)

Function

• hydrolyzes DNA under acidic conditions
• does not require divalent cations for activity
• participates in degradation of nuclear DNA during lens cell differentiation
• endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotide end-products

Structure

belongs to the Dnase II family

Compartment

lysosome (probable)

Alternative splicing

named isoforms=2

Expression

• highly expressed in the eye lens & in salivary gland
• detected at lower levels in lung, prostate & lymph node
• isoform 2 is lung specific

More general terms

• endodeoxyribonuclease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=58511
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:58511
• OMIM: https://mirror.omim.org/entry/608057
• UniProt: http://www.uniprot.org/uniprot/Q8WZ79.html