Kunitz-type protease inhibitor 1; hepatocyte growth factor activator inhibitor type 1; HAI-1 (SPINT1 HAI1 UNQ223/PRO256)

Function

• inhibitor of HGF activator
• also acts as an inhibitor of matriptase (ST14)
• interacts with HGFAC

Structure

• contains 2 BPTI/Kunitz inhibitor domains
• contains 1 LDL-receptor class A domain
• contains 1 MANSC domain

Compartment

secreted

Alternative splicing

named isoforms=2

More general terms

• Kunitz type serine protease inhibitor
• glycoprotein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6692
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6692
• OMIM: https://mirror.omim.org/entry/605123
• UniProt: http://www.uniprot.org/uniprot/O43278.html