transmembrane protease serine 11E; serine protease DESC1; transmembrane protease serine 11E2; contains: transmembrane protease serine 11E non-catalytic chain; transmembrane protease serine 11E catalytic chain (TMPRSS11E, DESC1, TMPRSS11E2, UNQ742/PRO1461)

Function

• serine protease
• has both gelatinase & caseinolytic activities
• preference for Arg in the P1 position (putative)

Structure

• N-glycosylated (putative)
• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 SEA domain

Compartment

• cell membrane
• single-pass type 2 membrane protein (putative)
• transmembrane protease serine 11E catalytic chain
• secreted (putative)
• activated by cleavage & secreted (putative)

Expression

• expression can only be detected in tissues derived from the head & neck, & in skin, prostate & testis

Notes

• uncertain whether Met-1 or Met-2 is the initiator

More general terms

• serine protease
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28983
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28983
• OMIM: https://mirror.omim.org/entry/610399
• UniProt: http://www.uniprot.org/uniprot/Q9UL52.html