kallikrein-15; ACO protease (KLK15)

Function

• protease, physiological substrate unknown

Structure

• belongs to the peptidase S1 family, kallikrein subfamily
• contains 1 peptidase S1 domain

Compartment

secreted (probable)

Alternative splicing

• named isoforms=4
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• highest expression in thyroid gland
• also expressed in prostate, salivary glands, adrenal glands, colon, testis & kidney

More general terms

• kallikrein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55554
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55554
• OMIM: https://mirror.omim.org/entry/610601
• UniProt: http://www.uniprot.org/uniprot/Q9H2R5.html