Na+ channel protein type 8 subunit alpha; Na+ channel protein type VIII subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.6 (SCN8A)

Function

• mediates voltage-dependent Na+ permeability of excitable membranes
• assumes opened or closed conformation in response to voltage difference across membrane
• forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient
• may be ubiquitinated by NEDD4L; which would promote its endocytosis (putative)
• interacts with NEDD4 & NEDD4L (putative)

Structure

• contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4)
• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every 3rd position
• belongs to the Na+ channel family
• contains 1 IQ domain

Compartment

membrane

Alternative splicing

named isoforms=4

More general terms

• voltage-dependent Na+ channel protein alpha subunit
• glycoprotein

Additional terms

• voltage-dependent Na+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6334
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6334
• OMIM: https://mirror.omim.org/entry/600702
• UniProt: http://www.uniprot.org/uniprot/Q9UQD0.html