K+ voltage-gated channel subfamily A member 3; voltage-gated K+ channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3 (KCNA3, HGK5)

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• assumes opened or closed conformation in response to voltage difference across membrane
• forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
• heterotetramer of K+ channel proteins
• binds PDZ domains of DLG1, DLG2 & DLG4 (putative)

Structure

• the N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, A (Shaker) subfamily

Compartment

membrane

Notes

uncertain whether Met-1 or Met-53 is the initiator

More general terms

• voltage-gated K+ channel alpha subunit
• glycoprotein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P22001.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3738
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3738
• OMIM: https://mirror.omim.org/entry/176263