voltage-dependent Ca+2 channel alpha-1
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Function
- alpha-1 subunit of the voltage-dependent Ca+2 channels forms the pore through which Ca+2 enters the cytoplasm
Compartment
- localized predominantly in dendrites Alternative-splicing:
- 2 isoforms of MW 210 & 240 KD that associate with N-type Ca+2 channels
Genetics
- at least 4 genes encode brain Ca+2-channel alpha-1 subunits with homology to the alpha-1 subunit of skeletal muscle L-type Ca+2-channels
More general terms
More specific terms
- voltage-dependent Ca+2 channel alpha-1A (voltage-dependent Ca+2 channel-alpha 1 isoform 4, L type, CACNA1A, CACNL1A4, CACH4, CACN3)
- voltage-dependent Ca+2 channel alpha-1B (N type, L-type Cav2.2, CACNA1B, CACNL1A5, CACH51)
- voltage-dependent Ca+2 channel alpha-1C (Ca+2 channel L type alpha-1 polypeptide isoform 1, cardiac muscle, Cav1.2, CACNA1C, CACNL1A1, CCHL1A1, CACH2, CACN2)
- voltage-dependent Ca+2 channel alpha-1D; Ca+2 channel L type alpha-1 polypeptide isoform 2; Cav1.3 (CACNA1D CACNL1A2, CCHL1A2, CACH3, CACN4)
- voltage-dependent Ca+2 channel alpha-1E (L type, Cav2.3, Calcium channel L type alpha-1 polypeptide, isoform 6, brain calcium channel II, CACNA1E, CACNL1A6, CACH6)
- voltage-dependent Ca+2 channel alpha-1F (L type, Cav1.4, CACNA1F, CACNAF1)
- voltage-dependent Ca+2 channel alpha-1G (T type, Cav3.1c, NBR13, CACNA1G, KIAA1123)
- voltage-dependent Ca+2 channel alpha-1H (T-type, Cav3.2, low-voltage-activated Ca+2 channel alpha1 3.2 subunit)
- voltage-dependent Ca+2 channel alpha-1i (T-type, Cav3.3, CACNA1I, KIAA1120)
- voltage-dependent Ca+2 channel alpha-1S (voltage-dependent Ca+2 channel-alpha 1 isoform 3 skeletal muscle, L type, CACNA1S, CACNL1A3, CACH1, CACN1,)
Component of
References
- ↑ Williams ME et al Structure and functional expression of an omega-conotoxin- sensitive human N-type calcium channel. Science. 1992 Jul 17;257(5068):389-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1321501
- ↑ Campbell KP et al The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. TINS 11:425 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469159
- ↑ Witcher DR, De Waard M, Sakamoto J, Franzini-Armstrong C, Pragnell M, Kahl SD, Campbell KP. Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. Science. 1993 Jul 23;261(5120):486-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8392754
- ↑ Westenbroek RE, Hell JW, Warner C, Dubel SJ, Snutch TP, Catterall WA. Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron. 1992 Dec;9(6):1099-115. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334419