voltage-dependent Ca+2 channel alpha-1E (L type, Cav2.3, Calcium channel L type alpha-1 polypeptide, isoform 6, brain calcium channel II, CACNA1E, CACNL1A6, CACH6)

Function

• pore-forming & voltage-sensitive alpha-1 subunit of voltage-sensitive Ca+2 channel
• alpha-1E gives rise to R-type Ca+2 currents
  • R-type Ca+2 channels belong to the 'high-voltage activated' (HVA) group
  • blocked by nickel, & partially by omega-agatoxin-IIIA (omega-Aga-IIIA)
  • insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), & omega-agatoxin-IVA (omega-Aga-IVA)
• Ca+2 channels contaning alpha-1E subunit may have role in modulation of firing patterns of neurons during information processing
• interacts with EFHC1
• alpha-1E is sufficient to generate voltage-sensitive Ca+2 channel activity

Structure

• each of the 4 internal repeats contains 5 hydrophobic transmembrane segments (S1, S2, S3, S5, S6) & one positively charged transmembrane segment (S4)
• S4 segments probably represent the voltage-sensor & are characterized by a series of positively charged amino acids at every third position
• belongs to the Ca+2 channel alpha-1 subunit (TC 1.A.1.11) family
• contains 1 EF-hand domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

expressed in neuronal tissues & in kidney

More general terms

• voltage-dependent Ca+2 channel alpha-1

Additional terms

• voltage-dependent Ca+2 channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=777
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:777
• OMIM: https://mirror.omim.org/entry/601013
• UniProt: http://www.uniprot.org/uniprot/Q15878.html