phosphatidylinositol [PI] glycan-specific phospholipase D1 (glycoprotein phospholipase D1, glycosyl-phosphatidylinositol specific phospholipase D1, GPLD1, PIGPLD1)
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Function
- hydrolyzes inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane
- hydrolysis of PI glycan occurs intracellularly
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O
<-->
6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate
Structure
Compartment
Alternative splicing
named isoforms=2
Expression
Comparative biology
- Gpld1 increases in mouse plasma after exercise[3]
- enhanced liver production of Gpld1 improves neurogenesis & cognition in mice[3]
More general terms
References
- ↑ Scallon BJ, Fung WJ, Tsang TC, Li S, Kado-Fong H, Huang KS, Kochan JP. Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D. Science. 1991 Apr 19;252(5004):446-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2017684
- ↑ UniProt http://www.uniprot.org/uniprot/P80108.html
- ↑ 3.0 3.1 3.2 3.3 Horowitz AM, Fan X, Bieri G et al. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science 2020 Jul 10; 369:167. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32646997 https://science.sciencemag.org/content/369/6500/167