inactive phospholipase C-like protein 1 (PLC-L1, phospholipase C-deleted in lung carcinoma, phospholipase C-related but catalytically inactive protein, PRIP, PLCL1)
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Function
- role in an inositol phospholipid-based intracellular signaling cascade.
- no PLC activity to phosphatidylinositol 4,5-bisphosphate & phosphatidylinositol
- component in the phospho-dependent endocytosis process of GABA A receptor
- regulates the turnover of receptors & thus contributes to the maintenance of GABA-mediated synaptic inhibition
- acts as a inhibitor of PPP1C
- interacts with PPP2CA (putative)
- interacts with ins(1,4,5)P3, ins(1,4,5,6)P4, GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits & PPP1C
- may form a ternary complex with GABA receptor beta subunit & GABARAP
- formation of ternary complex with GABA receptor beta subunit & GABARAP could be the key step for facilitating association of GABARAP with GABA receptor gamma-2 subunit & to allow it to be transported to the right destination
- phosphorylated by the catalytic subunit of PKA
- phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1 (putative)
Structure
- contains 1 C2 domain
- contains 1 PH domain
- contains 1 PI-PLC X-box domain lacks the essential His at position 458 which is replaced by a Asn thus inactive (prediction)
- contains 1 PI-PLC Y-box domain
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in a variety of fetal & adult organs including brain, lung & kidney
- isoform 1 is predominantly expressed in brain
Pathology
- aberrant expression could contribute to the genesis & progression of lung carcinoma
- expression greatly diminished in small-cell lung carcinoma & non-small-cell lung carcinoma