B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein, BCL9-like protein, Protein BCL9-2, BCL9L, DLNB11)

Function

• transcriptional regulator
• acts as an activator
• promotes beta-catenin transcriptional activity
• plays a role in tumorigenesis
• enhances neoplastic transforming activity of CTNNB1 (putative)
• found in a complex with CDC73, CTNNB1 & PYGO1
• interacts with CTNNB1

Structure

• C-terminal domain is important for its transactivation activity (putative)
• belongs to the BCL9 family

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

• expressed in fetal brain
• expressed in lung, amygdala, eye, prostate

Pathology

• BCL9L plays a role in tumorigenesis
• expressed in breast cancer,
  • ductal & invasive ductal carcinomas of the breast
  • sporadic colorectal adenomas & colorectal carcinomas (at protein level)
• expressed in pancreatic cancer & prostate cancer, head & neck cancer & embryonal tumor

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UU0.html