splicing factor, arginine/serine-rich 19; serine arginine-rich pre-mRNA splicing factor SR-A1; SR-A1, SR-related-CTD-associated factor; (SCAF1, SCAF, SFRS19, SRA1)

Function

• may function in pre-mRNA splicing (putative)
• interacts with POLR2A

Structure

belongs to the splicing factor SR family

Compartment

nucleus (probable)

Expression

• ubiquitous
• highly expressed in fetal brain & liver
• poorly expressed in salivary gland, heart, skin & ovary
• up-regulated by estrogens, androgens & glucocorticoids

Pathology

• over expressed in colorectal carcinomas & ovarian cancers

More general terms

• splicing factor; snRNP-associated protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H7N4.html