tRNA(His) guanylyltransferase (tRNA-histidine guanylyltransferase, Interphase cytoplasmic foci protein 45) (THG1L ICF45)

Function

• adds a GMP to the 5'-end of tRNA histidine after transcription & RNase P cleavage (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the tRNA(His) guanylyltransferase family

Compartment

• cytoplasm
• found near the nuclear membrane

Expression

expressed in many tissues

More general terms

• nucleotidyltransferase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NWX6.html